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IRIG pursuits further potential of egg.

Japanese

IRIGImmunology Research Institute in Gifu

Pursuing functions and potentials of chicken egg antibodies (IgY)

地図


Focusing on maternal immunity mechanism, after more than 20 years of continuous research IRIG has successfully developed many specific IgY against different pathogens in human and animals. As a result, IRIG is the owner of important patents on production and application of IgY.

Besides, our institute has published many scientific papers about IgY in various international journals.
Since its establishment in 1989, IRIG has undertaken many joint research projects with universities and research institutes in Japan and oversea countries.

Today we are focusing our activity on practical application of IgY. Our slogan is “IgY for a better life”. 


History of IRIG

1983 Establishment of Gifu laboratory.
    The aim was to develop new probiotics and vaccines for animals.

1985 Renamed into Gifu Laboratory of GHEN Corporation.

1986 Started basic research on IgY.

1989 Renamed into Immunology Research Institute in Gifu (IRIG).
    Put more effort on basic study of IgY and development of pharmaceutical products based on IgY.

1995 Renamed into Immunology Research in GHEN (IRIG).
    From this year the main focus was to study on application of IgY in feeds and foods.

2011 EW Nutrition Japan (EWNJ) was founded from Antibody Company of GHEN.
    IRIG was placed under management of EWNJ.


What is IgY ?

IgY and Passive Immunity


- Antibody transfer from mother to child -

In mammals, the fetus grows within its mother’s womb until it is sufficiently developed for birth. However, newborns lack the robust immune system required to defend themselves from the bacteria, viruses, and other pathogens that are ubiquitous outside the womb. For this reason newborns rely on antibodies transferred from the mother. This temporary reliance on the mother’s immune system after birth is called “maternal immunity.”

In humans, antibodies are transferred via
the placenta to the fetus pre-birth and via milk to the child post-partum. In other mammals as well antibodies are transferred from mother to child through milk.


-Avian maternal immunity-
The same maternal immunity system that protects mammalian offspring also exists in birds, although it inherently cannot rely on either placenta or milk (since birds have neither). The avian solution is to stock maternal antibodies in the egg, especially the yolk. Thus when the chick develops from the egg, it already possesses antibodies inherited from its mother to protect it from external pathogens.

-Passive immunity utilizing avian maternal immunity-
Immunity developed by an animal in the course of its own life is called “acquired immunity.” In contrast, the immunity acquired through external antibodies is called “passive immunity”. One example of passive immunity is to give IgY from birds to humans or livestock. If chickens are exposed to human or livestock pathogens, they create antibodies against these pathogens that are then accumulated in the chicken’s egg yolk. These chicken egg antibodies can be used to supply passive immunity for preventing infections and eliminating pathogens in both humans and livestock.

Immunology Research Institute in gifu

839-7, Sano, Gifu-City,

501-1101, Japan

TEL 058-235-7303